Mr Olivier Amar says “The secret to Kerastem advanced hair therapy, known as a stem cell hair loss treatment lies in your own natural body fat, which is particularly rich in regenerative cells with stem cells capabilities. Fat cells are essential ‘food’ for growing hair follicles. Restoring a fat and stem cell rich environment to the scalp creates a safe, powerful treatment for triggering growth and restoring lost hair.”
What is Kerastem advanced hair therapy?
Kerastem advanced hair therapy is a super enriched fat tissue transfer. It works by using your own natural fat and regenerative stem cells (stromal vascular fraction), injected into the scalp. Around 200-300cc of fat is extracted by liposuction and broken down through enzymatic digestion, producing on average 5ml of regenerative cells which contain adipose derived mesenchymal stem cells. A small amount of fat, 10-20cc depending on centimetre square of the scalp to be treated is processed separately through purification and reinjected into the scalp along with the regenerative stem cells. There, they combine to provide a rich, fertile environment which regenerates and stimulates the scalp. Patients treated with Kerastem experience thicker and fuller hair and see new hair growth in balding and thinning areas. Because this stem cell treatment only uses your own biological tissue, there is no risk of rejection or allergy.
Unlike a conventional hair transplant, a Kerastem stem cell hair loss treatment is subtle and discreet. Even though you see results faster than with a surgical transplant, there are no stitches, no scars and your hair grows in a natural way. Patients who are fit and healthy with typical male or female pattern baldness or alopecia and no other medical conditions can consider Kerastem stem cell hair loss treatment.
What happens during the procedure?
Kerastem stem cell hair loss treatment is performed as a surgical day case procedure under general anaesthesia or local anaesthesia. The procedure is minimally invasive and takes around 90 minutes. A small amount of fat is extracted from your abdomen by liposuction, around 200-300cc. The fat tissue is then broken down through enzymatic digestion to obtain the regenerative cells (stromal vascular fraction) which will be gently injected under the skin of the scalp. A small amount of fat is processed separately and mixed with the regenerative stem cells to create a super enriched fat which is injected into the scalp. There are no visible scars on the scalp after treatment, only some bruising which is to be expected with any injection. The recovery downtime is quite minimal and you can return to normal activity within 1-2 days of treatment.
Mr Amar can potentially extract more fat as part of a body contouring treatment,
How can I support my results?
Kerastem has brought back fat cells and regenerative cells to the scalp and through PRP treatment, the platelets can help to drive the cell division activation. PRP, also known as Platelet Rich Plasma, is a natural, non-surgical treatment that uses the regenerative power of your own blood. Blood contains platelets and other cells that naturally work to heal damaged or aged tissues. Platelets play a vital role in healing by releasing growth factors, which are proteins that stimulate the growth and repair of specific tissues.
Kerastem Publishes Successful US Phase 2 Hair Growth Clinical Trial Results
Low dose Adipose Derived Regenerative Cells (ADRCs) + Puregraft fat treatment group achieved a statistically significant increase in mean terminal hair count, at 6 months, when compared to control, in males with early (Grade III) stage hair loss relative to control, an average increase of 29 terminal (mature) hairs per cm2 of scalp was observed, corresponding to a 17% increase (p < 0.05).
All treatment arms of STYLE were safe with no serious adverse events reported.
“STYLE indicates that the dosing of this autologous cell product and tissue preparation can play a role in achieving a successful outcome," explained Principal Investigator Ken Washenik, M.D., Ph.D., Clinical Assistant Professor in the Ronald O. Perelman Department of Dermatology, NYU School of Medicine & Medical Director, Bosley Medical Group. "To identify the optimal procedure, we designed STYLE to evaluate controls with and without the addition of autologous fat as well as both high and lower doses of ADRCs doses and determined that 500,000 cells per square centimeter resulted in a superior outcome. In short, dose matters.”
Kerastem’s planned Phase 3 trial will support a Pre-Market Approval (PMA) filing in the United States for males with early hair loss. The company will also explore other product pipeline expansion opportunities including the Kerastem treatment for females with patterned hair loss.