Polynucleotides Treatment
Mr Olivier Amar - Leading Plastic Surgeon in Chelsea, London

Polynucleotides Treatment: Natural Bio-Stimulator for Skin Rejuvenation
What are Polynucleotides?
Polynucleotides are an injectable bio-stimulator treatment that harnesses natural polymerised polynucleotide based injectable gel technology to effectively restore skin firmness, tone and elasticity. Unlike traditional fillers, this innovative treatment works at the cellular level to promote natural skin regeneration. Polynucleotides deliver three powerful skin benefits:
- Deep moisturisation for lasting hydration
- Reduction of free radical damage to protect skin cells
- Enhanced collagen production for improved skin structure
The treatment involves a series of polynucleotide injections that stimulate skin regeneration from within. This comprehensive approach restores skin tone, enhances hydration and visibly reduces wrinkles, resulting in radiant, luminous skin with improved texture and diminished signs of ageing.
In skin texture management, Polynucleotides are the bridge between at home skin care, injectables by dermal filler and autologous PRP (plasma rich platelets).

Your consultation
Whether meeting in person or remotely, your consultation with Mr Olivier Amar provides a comprehensive discussion of your hoped for goals and treatment options. To get the most out of your consultation, we recommend reviewing information about your area of interest beforehand.
During your consultation, Mr Olivier Amar will listen to your desired outcomes and goals, conduct a thorough assessment, present appropriate treatment options and explain procedures in detail. This will include a step-by-step treatment process, required preparation, recovery timeline and potential risks and complications.
A consultation ensures you receive comprehensive information about all options, and understand both benefits and limitations of proposed procedures. You will have the opportunity to ask as many questions as you wish before you decide the next steps together, including the option to take no action.
Advanced Facial Rejuvenation
Mr Olivier Amar specialises in facial rejuvenation treatments. As every face is unique and we all age in different ways, he will conduct a comprehensive facial assessment, carefully developing a tailored approach to help patients achieve subtle, natural rejuvenation.
Risks associated with treatment
Every non-surgical treatment, while performed with the utmost care and expertise, carries inherent risks. Mr Olivier Amar ensures all patients are fully informed about potential complications before proceeding with any treatment.
General treatment side effects are generally mild and temporary, including redness, swelling, bruising and minor discomfort. During your consultation, Mr Olivier Amar will provide detailed information about procedure specific risks, explain preventive measures and safety protocols, answer all questions about potential complications and provide you with all the information needed to make an informed decision.
Preparing for Your Treatment
Aim to arrive to your appointment with your skin as best prepared for your Polynucleotides treatment as it can be.
Pre-treatment guidelines would ideally include:
• Avoid ibuprofen and aspirin 48 hours prior to treatment
• Avoid alcohol 2-3 days before treatment
• Get adequate rest the night before
• Eat a light meal and stay hydrated
• Clean skin thoroughly before treatment
Patients with a history of herpes simplex virus should be aware that, like many facial procedures, this treatment may trigger the virus and lead to cold sores. If you have experienced cold sores in the past, please inform us so we can prescribe preventative antiviral medication before your treatment.
Recovery Guide
Immediately after treatment you may experience bruising, mild redness, swelling, tenderness and itching at the site of the treated areas. Most patients find that any side effects subside within 2-3 days.
No downtime is required and you can resume normal activities immediately, avoiding strenuous exercise for 24 hours to prevent increasing blood flow to the face. As with all facial treatments, you should avoid direct sun exposure until any bruising subsides, continue using SPF 50+ protection and follow our recommended skincare routine.
Maintaining your results
Some patients will notice immediate results, while others may see gradual results that appear over time. Results depend on the age of the skin and concern being treated.
Most patients experience the best results within three months of completing the course of treatments, with a 4th treatment at four months to boost ongoing improvement. After this, results usually last for around six months and then most patients go on to repeat the treatment yearly. It is also recommended that you commit to wearing sun protection daily and follow an at home skincare regimen.
How do Polynucleotide Injections work?
Similar to hyaluronic acid dermal fillers in application technique, polynucleotides are administered through precise intradermal injections. However, they specifically target fine lines and improve skin texture without adding volume. This treatment improves the underlying skin layers, promoting healthier looking skin without creating separation between the dermis and epidermis.
Polynucleotide injections have gained popularity within the range of skin regenerative treatments supporting overall skin longevity and wellness. Premium brands like Plinest and Newest from Mastelli feature polymerised polynucleotide based injectable gels that stimulate fibroblasts, encouraging:
- Accelerated cell turnover
- Improved skin elasticity
- Boosted collagen production
- Enhanced skin hydration through powerful wound healing polymers
Why consider Polynucleotide Injections?
You might consider Polynucleotides treatment to:
- Significantly enhance skin hydration, circulation and overall skin quality
- Boost natural collagen and elastin production for comprehensive rejuvenation of under eyes, face, and neck
- Eliminate under eye hollows and shadows for a refreshed appearance
- Reduce lower eyelid fine lines and wrinkles
- Restore smooth, youthful facial contours
- Address crepey skin and fine lines on the neck and chest
- Soften facial wrinkles including forehead lines, brow lines, and nasolabial folds
Frequently Asked Questions
WHAT AREAS CAN BE TREATED with Polynucleotide injections?
Polynucleotides can treat the following areas:
- Under eyes and peri-orbital area
- Forehead and between the brows
- Nasolabial folds
- Around the mouth
- Jawline
- Neck
- Decolletage
- Hands
How many sessions will I need?
The recommended treatment is three sessions, two to three weeks apart with a fourth session at four months to boost ongoing improvement. Most patients go on to repeat the treatment yearly.
How are Polynucleotides different from dermal fillers?
Unlike dermal fillers that add volume, polynucleotides operate at the cellular level to trigger your skin’s natural renewal processes. Making polynucleotides ideal for patients looking for natural looking skin rejuvenation.
Polynucleotides
- Primary function: Skin regeneration and repair
- How it works: Stimulates fibroblasts to boost collagen and elastin production
- Results: Improved texture, elasticity and natural looking rejuvenation
Dermal Fillers
- Primary function: Volume enhancement
- How it works: Adds structural support to specific areas
- Results: Improved volume and definition
How does Polynucleotides treatment differ to Profhilo?
Polynucleotides treatment and Profhilo both offer distinct benefits for skin rejuvenation. Profhilo, containing high concentrations of hyaluronic acid, delivers immediate hydration benefits. Patients typically notice an instant luminous glow and improved skin texture shortly after treatment. Polynucleotides work at a deeper cellular level, stimulating fibroblast activity and promoting natural collagen production, with longer lasting skin quality improvements through skin repair and regeneration.
IS THE TREATMENT PAINFUL?
Most patients experience minimal discomfort. The needle used is very fine and the treatment involves several small injections.
HOW LONG DOES TREATMENT TAKE?
The treatment can take between 20 and 30 minutes, depending on the area being treated.
What type of Polynucleotides does Mr Amar offer?
Mr Olivier Amar uses premium brands like Plinest and Newest from Mastelli that feature polymerised polynucleotide based injectable gels that stimulate fibroblasts. The Mastelli range contain highly purified DNA fragments extracted from trout fish, which offers bio revitalisation treatments tailored to different concerns, goals and treatment areas. The key benefits include:
Plinest by Mastelli: Designed to revitalise skin and improve overall skin quality, addressing hydration, tone and texture, dull skin and fine lines
Plinest Eyes by Mastelli: Formulated to improve the skin around the eyes area, addressing dark circles, fine lines, crepey skin and puffiness
Newest by Mastelli:Uniquely formulated with polynucleotides (PN-HPT) and non-cross linked hyaluronic acid. This powerful combination delivers the dual benefits of both bio-stimulators and hyaluronic acid dermal fillers for powerful skin rejuvenation results
Meet Olivier Amar – Leading Plastic Surgeon in Chelsea, London
Mr Olivier Amar is a renowned London based consultant plastic, reconstructive and aesthetic surgeon specialising in face, breast and body surgery, advanced non-surgical facial rejuvenation, hair loss treatments and regenerative medicine. With over 15 years of experience, Mr Olivier Amar has earned a reputation among both patients and peers alike for transforming cosmetic surgery into an art form.
“Cosmetic surgery is a demanding profession and patient expectations are high. But I am a doctor first and a surgeon second. My only concern is the patient in front of me, fulfilling their needs and managing their expectations. My work is intense; it means everything to me and is my lifelong passion.”
Mr Amar’s commitment to precision and refinement extends through every aspect of patient care, from initial consultation to post-operative support. All treatments take place at his private practice in Chelsea, London. Working alongside Mr Amar is a highly skilled team of dedicated nurses, experienced anaesthetists from leading NHS and private hospitals, and specialised management staff. This collaborative approach ensures comprehensive, world class care for all patients.